‘You will be part of state-of-the-art Alzheimer’s research and therapies. Including deep and challenging insights.’
Presentation dr. Rudolph E. Tanzi
(Keynote speaker, presentation English spoken)
Addressing Age-Related Diseases: The Problem with the Brain
We are making great advances in surviving and managing cancer, heart disease, and diabetes. However, we are still not able to stop or even slow down Alzheimer’s disease.
To better understand Alzheimer’s disease and facilitate drug discovery, we used human stem cells to create human neurons expressing Alzheimer’s gene mutations in a 3D neural cell culture system. We provided the first ever evidence that, excess beta-amyloid deposition is sufficient to induce tangle formation and neuronal cell death, explaining the temporal pathological events of Alzheimer’s disease from plaques to tangles to neuronal cell death to inflammation.
Our new results suggest that it would be worth focusing on drug efforts aimed at lowering beta-amyloid deposition very early in life. In fact, we now have two different drugs in human clinical trials aimed at stopping amyloid formation in the brain as a means for preventing the onset of Alzheimer’s disease symptoms a decade or so later.
Lifestyle and The Self-Directed Biological Transformation Initiative
We have created the Self-Directed Biological Transformation Initiative (SBTI) research study, a multi-institutional collaboration examining the health benefits of traditional ayurvedic practices. Ayurveda dates back to roughly 5000 BC and focuses on a lifestyle balancing body, mind, and environment to maximize the body’s rejuvenating powers.
We are assessing the potential benefits of Ayurveda in a controlled trial design using mobile health sensors, genomics, cellular and molecular biology, metabolomics, lipidomics, microbiomics, telomerase assays, inflammatory biomarkers, Alzheimer’s biomarkers, and psychological outcomes.
The SBTI effectively marries ancient ayurvedic knowledge with state-of-the-art scientific methods to tesf for the benefits of a multi-faceted Ayurvedic approach on our physical, mental, and spiritual wellbeing. In essence, the SBTI is aimed at exploring and validating what we believe to be our own vast potential for health and spiritual wellbeing.
About dr. Rudolph E. Tanzi
– New York Times Bestselling Author
– Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University
– Vice-Chair of Neurology and Director of the Genetics and Aging Research Unit, at Massachusetts General Hospital
– Time 100 Most Influential People 2015
– 2015 Smithsonian American Ingenuity Award
Dr. Rudolph Tanzi is the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University, and Vice-Chair of Neurology and Director of the Genetics and Aging Research Unit at Massachusetts General Hospital.
Dr. Tanzi directs the Alzheimer’s Genome Project and over the past three decades discovered many of the genes responsible for Alzheimer’s disease genes and other neurological disease genes including that responsible for Wilson’s disease. He also developing several novel therapies for Alzheimer’s, two of which are in clinical trials in patients.
Dr. Tanzi has co-authored over 460 research articles, including three of the top ten most cited AD papers and contributes regularly to Huffington Post and San Francisco Chronicle. He also co-authored the popular trade books “Decoding Darkness: The Search for the Genetic Causes of Alzheimer’s Disease” and New York Times Bestseller, “Super Brain” with Dr. Deepak Chopra. Dr. Tanzi also hosts the nationwide public television special, “Super Brain with Dr. Rudolph Tanzi” that explores new discoveries in neuroscience to maximize the potential of the human brain in practical and actionable ways.
Dr. Tanzi serves on dozens of editorial and scientific advisory boards, and as Chair of the Cure Alzheimer’s Fund Research Consortium. He is the recipient of the two highest awards for Alzheimer’s disease research: The Metropolitan Life Award and The Potamkin Prize and also honored by The Chopra Foundation’s 2012 Rustum Roy Spirit Award for his exemplary work in the in science and serving humanity. Dr. Tanzi was included on the list of the “Harvard 100 Most Influential Alumni” by 02138 Magazine, and was chosen by the Geoffrey Beene Foundation as a “Rock Star of Science”. He was acknowledged by as one of the “World’s Most Influential Scientific Minds”, 2014” by Reuters-Thompson and one of the “Top 20 Translational Scientists, 2013″ by Nature Biotechnology. He is on the Time 100 list of “Most Influential People of the World 2015″. Most recently he received the 2015 Smithsonian American Ingenuity Award.
Described by The Boston Globe as the “rock star of science”, Dr. Tanzi has appeared on The Tonight Show with Jay Leno. His musical pursuits have lead him to perform the keyboards with Joe Perry, lead guitarist and co-founder of the legendary rock band, Aerosmith as well as appearing on Aerosmith’s 2012 album “Music From Another Dimension”. Perry has described Tanzi’s blend of science and music brilliance as “ the work ethic that Tanzi developed over years in the lab applies perfectly to his music” More recently, Dr. Tanzi has teamed up with singer/song-writer, Chris Mann, to create music and music videos promoting public awareness of Alzheimer’s disease.